Acetic Acid → Maltol

HRID 25910Notes

Reaction equation

HRID 25910 reaction equation
Cl[C:2]1[C:3](=[O:11])[CH:4]([CH3:10])[O:5][CH:6](OC)[CH:7]=1.C(O)(=[O:14])C>>[CH3:10][C:4]1[O:5][CH:6]=[CH:7][C:2](=[O:14])[C:3]=1[OH:11]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 3251214-chloro-6-methoxy-2-methyl-2H-pyran-3(6H)-one

Product 1

HCID 8369MaltolYield 65%

Procedure

To a round bottom flask equipped with a stirring bar and a condenser was added 4-chloro-6-methoxy-2-methyl-2H-pyran-3(6H)-one and acetic acid and the reaction mixture heated to reflux for an hour. Maltol (65%) was obtained on cooling.

Workup

  1. customTo a round bottom flask equipped with a stirring bar and a condenser
  2. temperaturethe reaction mixture heated
  3. temperatureto reflux for an hour

Sources & evidence

ORD record
ord-a016637cd0fc411cbf0abfd38badaa5b
Source dataset
uspto-grants-1979_04
Patent number
US04147705

Reaction notes

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