2,3-Dibromo-N-[(4-chlorophenyl)carbamoyl]propanamide → 1-(4-Chlorophenyl)-5-methylideneimidazolidine-2,4-dione

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Reaction Steps

25.0 g of the N-(4-chlorophenyl)-N'-(2,3-dibromopropionyl)-urea obtained in accordance with Example 4(b) are heated under reflux for 1 hour with 26.0 g of potassium tert.-butylate (90%) in 250 ml of tert.-butanol. The solvent is then distilled off under normal pressure and the residue is heated in vacuo for 20 minutes to 120° C. The reaction product is taken up with 500 ml of water at 60° C, precipitated with dilute acetic acid, filtered and dried. Yield: 12.0 g, m.p: 185° - 187° C.

Provenance & Evidence