Thionyl Chloride → HCID 21424023, compound

HRID 259268Notes

Reaction equation

HRID 259268 reaction equation
[CH2:1]([O:13][CH2:14][CH:15](O)[CH2:16][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].S(Cl)([Cl:25])=O>>[Cl:25][CH:15]([CH2:14][O:13][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:16][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21423865HCID 21423865, compound

Product 1

HCID 21424023HCID 21424023, compound

Procedure

Thionyl chloride (10 ml.) and 1.55 g. of 1-[3'-(n-dodecyloxy)-2'-hydroxypropyl]imidazole are warmed gently for a period of 2 hours and the solution is then evaporated to dryness. The residue is dissolved in 100 ml. of dichloromethane and rendered basic with aqueous potassium carbonate solution. The organic layer is separated, dried over magnesium sulfate and evaporated to yield 1-[2'-chloro-3'-(n-dodecyloxy)propyl]imidazole.

Workup

  1. customthe solution is then evaporated to dryness
  2. dissolutionThe residue is dissolved in 100 ml
  3. customThe organic layer is separated
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-905d5ad7a4874a8ab2a131c0d1646c70
Source dataset
uspto-grants-1977_07
Patent number
US04036974

Reaction notes

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