Thionyl Chloride → HCID 21423710, compound

HRID 259276Notes

Reaction equation

HRID 259276 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH:10](O)[CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O>>[ClH:1].[Cl:20][CH:10]([CH2:9][S:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH2:11][N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 13688958HCID 13688958, compound

Product 1

HCID 21423710HCID 21423710, compound

Procedure

1-[3'-(4"-chlorophenylthio)-2'-hydroxypropyl]imidazole (2.0 g.) and 10 ml. thionyl chloride are warmed gently for 2 hours. Thereafter, the reaction mixture is evaporated to dryness to yield 1-[2'-chloro-3'-(4"-chlorophenylthio)propyl]imidazole hydrochloride as a gum. The gum is dissolved in dichloromethane (100 ml.), basified with aqueous potassium carbonate solution and the organic phase dried over magnesium sulfate and evaporated.

Workup

  1. customThereafter, the reaction mixture is evaporated to dryness

Sources & evidence

ORD record
ord-96d3e59e03bf4a3d87659a0f5db91c58
Source dataset
uspto-grants-1977_07
Patent number
US04036970

Reaction notes

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