Thionyl Chloride → HCID 21423872, compound

HRID 259279Notes

Reaction equation

HRID 259279 reaction equation
S(Cl)([Cl:3])=O.[CH2:5]([O:15][CH2:16][CH:17](O)[CH2:18][N:19]1[CH:23]=[CH:22][N:21]=[CH:20]1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]>>[Cl:3][CH:17]([CH2:16][O:15][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:18][N:19]1[CH:23]=[CH:22][N:21]=[CH:20]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21423822HCID 21423822, compound

Product 1

HCID 21423872HCID 21423872, compound

Procedure

Thionyl chloride (5 ml.) and 1.6 g. of 1-[3'-(n-decyloxy)-2'-hydroxypropyl]imidazole are warmed gently for a period of 2 hours and the solution is then evaporated to dryness. The residue is dissolved in dichloromethane and rendered basic with aqueous potassium carbonate solution. The organic layer is separated, dried over magnesium sulfate and evaporated to yield 1-[2'-chloro-3'-(n-decyloxy)propyl]imidazole.

Workup

  1. customthe solution is then evaporated to dryness
  2. dissolutionThe residue is dissolved in dichloromethane
  3. customThe organic layer is separated
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-966ae92cd1194d36a92d34724a99c112
Source dataset
uspto-grants-1977_07
Patent number
US04036973

Reaction notes

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