5-Methyl-1,2-oxazole-3-carbaldehyde → 1-{[(5-Methyl-1,2-oxazol-3-yl)methylidene]amino}imidazolidin-2-one

HRID 25928Notes

Reaction equation

HRID 25928 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH:7]=O)[CH:3]=1.Cl.[NH2:10][N:11]1[CH2:15][CH2:14][NH:13][C:12]1=[O:16]>O>[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH:7]=[N:10][N:11]2[CH2:15][CH2:14][NH:13][C:12]2=[O:16])[CH:3]=1

Participants

4

Reactant 2

HCID 27952225-Methyl-1,2-oxazole-3-carbaldehydeHCID 192616781-Amino-2-imidazolidinone hydrochloride

Product 1

HCID 542211301-{[(5-Methyl-1,2-oxazol-3-yl)methylidene]amino}imidazolidin-2-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

14.0 pts. by wt. of 5-methyl-3-formyl-isoxazole are reacted with 25.6 pts. by wt. of 1-amino-2-oxo-imidazolidine hydrochloride in 100 pts. by vol. of water as in Example 25.1. After 90 minutes, the precipitate is filtered off, washed with water, dried and recrystallised from absolute acetonitrile. 12.5 pts. by wt. of 1-(5-methyl-isoxazol-3-yl-methyleneamino)-2-oxo-imidazolidine of melting point 195°-7° C. are obtained.

Workup

  1. filtrationthe precipitate is filtered off
  2. washwashed with water
  3. customdried
  4. customrecrystallised from absolute acetonitrile

Sources & evidence

ORD record
ord-139d17def34245298714a3e2a6ba331f
Source dataset
uspto-grants-1979_04
Patent number
US04147693

Reaction notes

Loading…