Sodium Hydroxide → HCID 178528004, compound

Participants

Reaction Steps

Cyclopentylmercaptan (ca 1.5g, 0.015M) was added to a solution of sodium hydroxide (0.6g, 0.015M) in water (3 ml). Dioxan (45 ml) was added, followed by chloroacetylferrocene (3.9g, 0.015M), and the mixture was heated at 100° for 2 hours with stirring. On cooling, water was added to the reaction mixture which was then extracted with chloroform. The organic layer was washed with dilute sodium hydroxide and water before it was dried over anhydrous magnesium sulphate and evaporated to an oil on a rotary evaporator. The product was isolated after column chromatography on silica gel using gradient elution with 1-21/2% (v/v) ethyl acetate in petroleum ether (60-80). Orange needles (0.40g) of the title compound were obtained mp = 78°-9°.

Provenance & Evidence