反应详情

β-phenoxyethyl 4-bromo-3-methyl-2-butenoate (15g) obtained in Example 7 was refluxed with anhydrous sodium acetate (5.32g) in glacial acetic acid (15g) for 8 hours. Ethylether (300ml) and water (20ml) were added to the reaction mixture and the ether layer was washed with water, dried, and concentrated, giving a crude product (11.7g). The crude product on fractionation gave a fractionation gave a fraction (6.1g), b.p. 165°-168° C./0.6mmHg. Structural assignment for this compound was made from its infrared absorption spectrum; 1738, 1710, 1658, 1600, 1590, 1500, 1240, 1215, 1145, 1055, 1040, 755, and 690cm-1.

1. washthe ether layer was washed with water
2. customdried
3. concentrationconcentrated
4. customgiving a crude product (11.7g)