Methanamine, N-methoxy-, hydrochloride (1:1) → 1-Methoxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

HRID 259319Notes

Reaction equation

HRID 259319 reaction equation
Cl.[CH3:2][NH:3][O:4][CH3:5].[S:6]1[CH:10]=[CH:9][C:8]2[CH:11]([N:15]=[C:16]=[O:17])[CH2:12][CH2:13][CH2:14][C:7]1=2>>[CH3:5][O:4][N:3]([CH3:2])[C:16]([NH:15][CH:11]1[C:8]2[CH:9]=[CH:10][S:6][C:7]=2[CH2:14][CH2:13][CH2:12]1)=[O:17]

Participants

3

Reactant 2

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 205373014-Isocyanato-4,5,6,7-tetrahydro-1-benzothiophene

Product 1

HCID 203489501-Methoxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

Procedure

Following the procedure described in Example 6, N,O-dimethyl hydroxylamine hydrochloride and 4,5,6,7-tetrahydrobenzo[b]thien-4-yl isocyanate are allowed to react to give 1-methoxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, which is crystallized from acetone-hexane-ether to give product melting at 60° C. to 62.5° C.

Workup

  1. customto react

Sources & evidence

ORD record
ord-30221d514f154ef59f0b74de114f528f
Source dataset
uspto-grants-1977_07
Patent number
US04036979

Reaction notes

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