反应详情

A solution of 6.27 grams of 4,5,6,7-tetrahydrobenzo[b]thien-4-yl isocyanate in 200 ml. of diethyl ether is charged with gaseous dimethylamine introduced via a capillary tube with stirring. After 0.5 hour of bubbling, the gas flow is terminated, and the mixture is evaporated to dryness to give a solid residue. This is crystallized from acetone-hexane-ether to give 1,1-dimethyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea melting at 117° C. to 120° C.

1. additionintroduced via a capillary tube
2. customAfter 0.5 hour of bubbling
3. customthe gas flow is terminated
4. customthe mixture is evaporated to dryness
5. customto give a solid residue
6. customThis is crystallized from acetone-hexane-ether