Diethyl Ether → HCID 20342206, compound

Participants

Reaction Steps

To 29.8 g (0.100 mole) of N-[4-(1-adamantyloxy)phenyl]pyrrolidine dissolved in CH2Cl2 (200 ml) and diethyl ether (25 ml) stirred and cooled in an ice bath is added in one portion 44 ml of 3.4 N HCl in ether (0.15 mole of HCl). After 30 minutes' stirring, the solvent is evaporated. The resulting solid (33.8 g) is recrystallized from CH2Cl2 (120 ml) - diethyl ether (100 ml) to give 29.0 g of white solid product, mp (in bath at 148°; 1°/minute temperature rise), 163.4°-166.8° C. Nmr, ir, and UV spectra were in accord with the structure.

Provenance & Evidence