Water → 1,4,6-Trimethyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

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Reaction Steps

To a stirred mixture of 1 -methyl-3-cyano-4,6-dimethyl-pyrid-2-one (144 g., 0.89 mole) and 110 ml. of water is slowly added concentrated sulfuric acid (220 ml.) and the solution is heated on a steam bath for 24 hours. The solution is poured into 6 liters of water, cooled, and the resulting precipitate is collected by filtration and dried in a vacuum oven to give 1-methyl-3-carboxy-4,6-dimethylpyrid-2-one, 97 g. (60% yield), mp. 200°-204° C.

Provenance & Evidence