Isobutylamine → 2-cyano-N-isobutylacetamide

HRID 259372Notes

Reaction equation

[C:1]([CH2:3][C:4]([O:6]CC)=O)#[N:2].[CH2:9]([NH2:13])[CH:10]([CH3:12])[CH3:11]>>[CH2:9]([NH:13][C:4](=[O:6])[CH2:3][C:1]#[N:2])[CH:10]([CH3:12])[CH3:11]

Participants

Reactant 2

HCID 6558Isobutylamine

HCID 7764Ethyl cyanoacetate

Product 1

HCID 45865672-cyano-N-isobutylacetamide

Procedure

Ethyl cyanoacetate (113 g., 1.0 mole) and isobutylamine (73 g., 1.0 mole) were refluxed with stirring for 2 hours to give N-isobutyl cyanoacetamide.

Sources & evidence

ORD record: ord-a7346cae65e04c14955e8f8a0def31b0
Source dataset: uspto-grants-1977_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04038065

Reaction notes

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