Propane, 1-chloro-3-isocyanato- → HCID 70610686, compound

HRID 259398Notes

Reaction equation

HRID 259398 reaction equation
[NH2:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:15]=[C:16]([CH3:20])[CH:17]=[CH:18][CH:19]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[Cl:23][CH2:24][CH2:25][CH2:26][N:27]=[C:28]=[O:29]>C1(C)C=CC=CC=1>[Cl:23][CH2:24][CH2:25][CH2:26][NH:27][C:28](=[O:29])[NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:15]=[C:16]([CH3:20])[CH:17]=[CH:18][CH:19]=3)[CH2:10][CH2:9]2)=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 166752Propane, 1-chloro-3-isocyanato-HCID 22751185HCID 22751185, compound

Product 1

HCID 70610686HCID 70610686, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

11.3 gm (38.5 millimols) of N-(p-amino-phenethyl)-N'-(m-tolyl)-piperazine, 4.6 gm (38.5 millimols) of 3-chloropropyl-isocyanate and 120 ml of toluene were admixed with each other, accompanied by gentle agitation, and the mixture was allowed to react for two hours and was then vacuum-filtered, yielding as the filter cake 90% of theory of N-[p-(3-chloropropyl-ureido)-phenethyl]-N'-(m-tolyl)-piperazine, m.p. 168° C.

Workup

  1. customto react for two hours
  2. filtrationwas then vacuum-filtered

Sources & evidence

ORD record
ord-e63724d261be47e89655a0f4d30e4bf5
Source dataset
uspto-grants-1977_07
Patent number
US04038279

Reaction notes

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