Iodoethane → HCID 21421712, compound

Participants

Reaction Steps

25.3 g. of (4-hydroxy-2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone (0.1 mol.), 17.1 g. of ethyl iodide (0.11 mol.) and 5 g. of sodium hydroxide are heated together in 150 ml. of dimethylformamide for 12 hours with continuous stirring at 100°. The mixture is filtered hot, evaporated to dryness and the residue is recrystallized from butanol to obtain 5-benzoyl-7-ethyl-2,7-dihydro-2-methyl-4H-pyrazolo[3,4-b]pyridin-4-one, yield 20.3 g. (72%); m.p. 217°-218°.

Provenance & Evidence