Potassium Carbonate → HCID 21421722, compound

Participants

Reaction Steps

5.1 g. of (4-hydroxy-2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone (0.02 mol.), 4.8 g. of dimethylaminopropyl chloride (0.04 mol.) and 5.6 g. of potassium carbonate (0.04 mol.) are heated in 50 ml. of dimethylformamide at 80° for 12 hours with stirring. The mixture is filtered hot, evaporated to dryness and the residue is recrystallized from ethyl acetate to obtain 5-benzoyl-7-[3-(dimethylamino)Propyl]-2,7-dihydro-2-methyl-4H-pyrazolo[3,4-b]pyridin-4-one, yield 4.6 g. (68%); m.p. 186°-188°.

Provenance & Evidence