Potassium Hydroxide → HCID 21421717, compound

HRID 259407Notes

Reaction equation

HRID 259407 reaction equation
[CH2:1]([N:3]1[CH:8]=[C:7]([C:9]([O:11]CC)=[O:10])[C:6](=[O:14])[C:5]2=[CH:15][N:16]([CH3:18])[N:17]=[C:4]12)[CH3:2].[OH-].[K+]>C(O)C>[CH2:1]([N:3]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[C:6](=[O:14])[C:5]2=[CH:15][N:16]([CH3:18])[N:17]=[C:4]12)[CH3:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 86734967HCID 86734967, compound

Product 1

HCID 21421717HCID 21421717, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

24.9 g. of 7-ethyl-4,7-dihydro-2-methyl-4-oxo-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester (0.1 mol.) are treated with 10 g. of potassium hydroxide in 100 ml. of ethyl alcohol at reflux temperature for 12 hours with stirring. The solvent is removed in vacuo and the crystalline, residual potassium salt is dissolved in 100 ml. of water. After acidifying the solution with acetic acid, 7-ethyl-4,7-dihydro-2-methyl-4-oxo-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid crystallizes, yield 19 g. (68%); m.p. 273°-275° (DMF).

Workup

  1. customThe solvent is removed in vacuo
  2. dissolutionthe crystalline, residual potassium salt is dissolved in 100 ml
  3. customcrystallizes

Sources & evidence

ORD record
ord-49c2f5e7a1804ed29d774e918c309203
Source dataset
uspto-grants-1977_07
Patent number
US04038281

Reaction notes

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