Methanol → HCID 23454360, compound

HRID 259437Notes

Reaction equation

HRID 259437 reaction equation
[OH:1][C:2]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:6](=[O:7])[C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:10][CH:9]=2)=[CH:4][O:3]1.[CH3:25]O>>[CH3:25][O:1][C:2]1([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:6](=[O:7])[C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:13]=2)=[CH:4][O:3]1

Participants

3

Reactant 2

HCID 887MethanolHCID 20304491HCID 20304491, compound

Product 1

HCID 23454360HCID 23454360, compoundYield 83%

Procedure

A solution of 3.36 g of 2-hydroxy-2-phenyl-4-[4-(2-carboxyethyl)phenyl]-3(2H)-furanone in 150 ml of methanol was heated under reflux under a nitrogen atmosphere for 17 hrs. The reaction mixture was evaporated and the residue was recrystallized from methylene chloride-petroleum ether to give 2.28 g (83%) of 2-methoxy-2-phenyl-4-[4-(2-carboxyethyl)phenyl]-3(2H)-furanone as colorless crystals, m.p. 117°-120° C., after drying at 50° C. for 1 hr. under vacuum.

Workup

  1. temperatureunder reflux under a nitrogen atmosphere for 17 hrs
  2. customThe reaction mixture was evaporated
  3. customthe residue was recrystallized from methylene chloride-petroleum ether

Sources & evidence

ORD record
ord-82ba176756e74f25b98f25c1e60b5233
Source dataset
uspto-grants-1977_07
Patent number
US04038289

Reaction notes

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