反应详情

To a solution of 5.63 g of 3-(4-carboxyphenyl)-1-phenyl-2,3-epoxy-1-propanone in 100 ml of ethanol at 85°-90° C. was added a solution of 6 g of potassium hydroxide in 100 ml of ethanol with stirring over 5 min. The reaction mixture was heated at 85°-90° C. for 5 min. and then allowed to cool to room temperature. The solution was evaporated to dryness and the residue was dissolved in 300 ml of ice-water and acidified with 125 ml of hydrochloric acid. After stirring for 30 min., the precipitate was collected and washed with water. The precipitate was dissolved in 600 ml of ethyl acetate and the solution was dried and filtered. The filtrate was evaporated to give 5.63 g (100%) of 3-(4-carboxyphenyl)-1-phenyl-1,2-propanedione as a yellow solid.

1. temperatureThe reaction mixture was heated at 85°-90° C. for 5 min.
2. customThe solution was evaporated to dryness
3. dissolutionthe residue was dissolved in 300 ml of ice-water
4. stirringAfter stirring for 30 min.
5. customthe precipitate was collected
6. washwashed with water
7. dissolutionThe precipitate was dissolved in 600 ml of ethyl acetate
8. customthe solution was dried
9. filtrationfiltered
10. customThe filtrate was evaporated