HCID 178423608, compound → HCID 178423609, compound

HRID 259515Notes

Reaction equation

HRID 259515 reaction equation
[CH3:1][C:2]1[C:3]2[C:8]([CH:9]=[CH:10][CH:11]=1)=[N+:7]([O-:12])[C:6]([C:13]([NH2:15])=[O:14])=[C:5]([CH2:16]Br)[N+:4]=2[O-:18].[CH3:19][N:20]1[CH:24]=[CH:23][N:22]=[C:21]1[SH:25]>C(Cl)(Cl)Cl>[CH3:1][C:2]1[C:3]2[C:8]([CH:9]=[CH:10][CH:11]=1)=[N+:7]([O-:12])[C:6]([C:13]([NH2:15])=[O:14])=[C:5]([CH2:16][S:25][C:21]1[N:20]([CH3:19])[CH:24]=[CH:23][N:22]=1)[N+:4]=2[O-:18]

Participants

4

Reactant 2

HCID 178423608HCID 178423608, compoundHCID 178480602HCID 178480602, compound

Product 1

HCID 178423609HCID 178423609, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Methyl 3-bromomethyl-2-quinoxalinecarboxamide-1,4-dioxide (0.24 moles) was suspended in 1 liter of chloroform with stirring and N-methyl-2-mercaptoimidazole (0.24 moles) was added as a solid. A complete solution resulted within 10 minutes. The solution was stirred overnight at room temperature during which time the desired product crystallized as the hydrobromide. The product was collected by filtration and dried. Yield, 96 grams (91%); m.p. 148°-52° C.

Workup

  1. customA complete solution resulted within 10 minutes

Sources & evidence

ORD record
ord-91f3993508f34f31bf32e9371873f0d0
Source dataset
uspto-grants-1977_07
Patent number
US04038392

Reaction notes

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