Bromine → HCID 178526280, compound

HRID 259518Notes

Reaction equation

HRID 259518 reaction equation
[OH:1][CH2:2][C:3]1[C:12]([CH3:13])=[N+:11]([O-:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N+:4]=1[O-:15].[Br:16]Br>CO>[Br:16][CH2:13][C:12]1[C:3]([CH2:2][OH:1])=[N+:4]([O-:15])[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N+:11]=1[O-:14]

Participants

4

Reactant 2

HCID 24408BromineHCID 178429581HCID 178429581, compound

Product 1

HCID 178526280HCID 178526280, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Hydroxymethyl-3-methylquinoxaline-1,4-dioxide (1 mole) was suspended in 5 liters of methanol and stirred while bromine (1.06 moles) was added dropwise over 1.5 hours. The reaction mixture was stirred for 5 days. The product was collected by filtration and washed with 1 liter of ether/400 ml methanol and then with 1 liter of ether. Yield, 175 grams (61%); m.p. 149°-150° C.

Workup

  1. additionwas added dropwise over 1.5 hours
  2. filtrationThe product was collected by filtration
  3. washwashed with 1 liter of ether/400 ml methanol
  4. customYield

Sources & evidence

ORD record
ord-c5b3bd05183849529fa41ee1ffbc4a33
Source dataset
uspto-grants-1977_07
Patent number
US04038392

Reaction notes

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