HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic Acid → 5-Methyl-2-phenyloxazolo[4,5-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | 2-Amino-6-methylpyridin-3-ol | HCID 88500 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | 5-Methyl-2-phenyloxazolo[4,5-b]pyridine | HCID 19990483 | — |
Reaction Steps
A mixture of 1.25 g. of 2-amino-3-hydroxy-6-methylpyridine, 6 g. of polyphosphoric acid and 2.0 g. benzoic acid was heated at 190°-200° C. for 10 minutes. The cooled mixture was diluted with water and basified with solid sodium bicarbonate. The resulting precipitate was collected and recrystallized from ether to give 5-methyl-2-phenyloxazolo[4,5-b]pyridine, m.p. 148°-149° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04038396 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-a16325806c624308b48649d43b70c8ea |
| Source note | uspto-grants-1977_07 |