反应详情

A solution of 3.1 g. of 3-amino-5-methyl-2-pyridone in 25 ml. of pyridine was cooled in ice and treated with 4.5 g. of 2-fluorobenzoyl chloride dropwise. After stirring about 3 hours at room temperature, the mixture was diluted with 200 ml. of ice-water. After 0.5 hour the precipitate was collected, washed with water, dried and recrystallized from ethanol to give 3-(2-fluorobenzoylamino)-5-methyl-2-pyridone, m.p. 230°-232° C.

1. additiontreated with 4.5 g
2. additionthe mixture was diluted with 200 ml
3. customAfter 0.5 hour the precipitate was collected
4. washwashed with water
5. customdried
6. customrecrystallized from ethanol