反应详情

Bromine (0.02 mol) was added dropwise to a stirred solution of 2-(α-methylbenzyl)acetophenone (0.02 mol) in dry diethyl ether (20 ml) at 5° over one hour. The ether was removed in vacuo and the residue redissolved in ether (100 ml), washed with saturated sodium bicarbonate solution (2 × 100 ml) and then water (4 × 100 ml), and dried over anhydrous sodium sulphate. Removal of the solvent gave a solid which on recrystallisation from petroleum ether (40°-60°) gave 2-bromo-3-phenylbutyrophenone, m.p. 69°-71°.

1. customThe ether was removed in vacuo
2. dissolutionthe residue redissolved in ether (100 ml)
3. washwashed with saturated sodium bicarbonate solution (2 × 100 ml)
4. dry with materialwater (4 × 100 ml), and dried over anhydrous sodium sulphate
5. customRemoval of the solvent
6. customgave a solid which
7. customon recrystallisation from petroleum ether (40°-60°)