HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → 1-[p-(2-Methoxycarbonylaminovinyl)-phenoxy]-2-hydroxy-3-isopropylamino-propane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 1-[p-(2-Methoxycarbonylaminovinyl)-phenoxy]-2,3-epoxypropane | HCID 54361820 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-[p-(2-Methoxycarbonylaminovinyl)-phenoxy]-2-hydroxy-3-isopropylamino-propane | HCID 53976105 | — |
Reaction Steps
9.4 g (0.038 mol) of 1-[p-(2-methoxycarbonylaminovinyl)-phenoxy]-2,3-epoxy-propane are dissolved in 200 ml of isopropanol, 3.25 ml (0.038 mol) of isopropylamine are added and thereafter the mixture is heated to the boil for 3 hours, under a reflux condenser. It is then evaporated in vacuo and the resulting crude base is crystallised from acetone-ether. 1-[p-(2-Methoxycarbonylaminovinyl)-phenoxy]-2-hydroxy-3-isopropylamino-propane of melting point 128°-129° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04038414 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-6a51a1574e434663b449663f7707e39b |
| Source note | uspto-grants-1977_07 |