Benzaldehyde → HCID 53750027, compound

Participants

Reaction Steps

8 g (0.0324 mole) of 1-(4-hydroxyphenyl)-2-(4-chlorophenyl)ethanone (prepared by Friedel-Craft reaction between methoxybenzene and 4-chlorophenylacetylchloride, followed by demethylation of the methyl ether with pyridine hydrochloride) was treated with 3.44 g (0.0324 mole) of benzaldehyde and 2.58 g (0.304 mole) of piperidine in 15 ml of methanol at 60° C. and worked up as under Example IA gave 9.0 g of crude product. 8.5 g of this material on refluxing with 85 ml of glacial acetic acid for 4 hours and was worked up as under Example IB. Trituration with hot methanol and cooling gave 3 g (44.5%) of crystalline material, m.p. 228°.

Provenance & Evidence