Isobutyraldehyde → 1-Benzhydrylamino-2-methylpropanephosphonous acid

HRID 25974Notes

Reaction equation

HRID 25974 reaction equation
[CH:1](=O)[CH:2]([CH3:4])[CH3:3].[PH2:6]([O-:8])=[O:7].[CH:9]([NH3+:22])([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(O)C>[CH:9]([NH:22][CH:1]([P:6]([OH:8])[OH:7])[CH:2]([CH3:4])[CH3:3])([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 6561IsobutyraldehydeHCID 178527021HCID 178527021, compound

Product 1

HCID 213258821-Benzhydrylamino-2-methylpropanephosphonous acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

19.8 parts of isobutyraldehyde and 62.2 parts of benzhydrylammonium hypophosphite were dissolved in 75 parts of ethanol and the mixture was heated at reflux for 3 hours. After cooling the mixture was filtered to give DL-1-benzhydrylamino-2-methyl-propanephosphonous acid of melting point 189°-192°.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 3 hours
  3. temperatureAfter cooling the mixture
  4. filtrationwas filtered

Sources & evidence

ORD record
ord-88a1f3332b3f4b068023d580c6177fba
Source dataset
uspto-grants-1979_04
Patent number
US04147780

Reaction notes

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