Hydrochloric Acid → HCID 18930706, compound

Participants

Reaction Steps

A mixture of N-BOC amine 1d (0.20 g, 0.45 mmol) and 4 M hydrogen chloride in 1,4-dioxane (1.0 mL) was stirred at room temperature under a CaSO4 drying tube for 3.3 h. Dilution with diethyl ether produced a precipitate, which was collected by filtration and dried to give a yellow powder (0.17 g). 1H-NMR(300 MHz, d6 -DMSO): 13.1 (br, 1H), 8.09 (br, 3H), 7.87-7.82 (m, 3H), 7.78 and 7.74 (AB quartet, 2H, J=15 Hz), 7.63 (s, 1H), 7.53 (t, 1H, J=8 Hz), 7.28 (dd, 1H, J=8,2 Hz), 7.01 (d, 2H, J=9Hz), 4.78 (s, 2H), 4.30-4.26 (m, 2H), 3.36 (br, 2H). HR-MS: Calc. 342.1341, Found 342.1349. IR(KBr) cm-1 3398, 1744, 1656.

Provenance & Evidence