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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 259775Generated: October 25, 2026

2,5-Dihydroxybenzoic acid → Methyl Gentisate

https://huagongshe.com/reaction/259775

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,5-Dihydroxybenzoic acidHCID 3469—
ReactantEthyl 5-formyl-2-hydroxybenzoateHCID 18930679—
SolventMethanolHCID 887—
ProductMethyl GentisateHCID 7507794%

Reaction Steps

2,5-Dihydroxybenzoic acid was converted to its methyl ester using catalytic sulfuric acid in methanol following the same protocol as for esterification 2c in 94% yield. mp 86.4°-88.5° C. IR(KBr): cm-1 3346, 1684.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05523302
Source datasetuspto-grants-1996_06
ORD IDord-a951e7e6815d485cb58f68faeb832be4
Source noteuspto-grants-1996_06