Trifluoroacetic acid methylene chloride → HCID 131719424, compound

HRID 259789Notes

Reaction equation

HRID 259789 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[C:16]([C@@H:18]2[CH2:20][C@H:19]2[C:21](=[O:41])[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([N:28]3[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]3)[CH:23]=2)[CH:15]=[CH:14][C:4]=1[O:5][CH2:6][C:7]([O:9]C(C)(C)C)=[O:8].[C:42]([OH:48])([C:44]([F:47])([F:46])[F:45])=[O:43].C(Cl)Cl>>[CH3:1][O:2][C:3]1[CH:17]=[C:16]([C@@H:18]2[CH2:20][C@H:19]2[C:21](=[O:41])[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([N:28]3[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]3)[CH:23]=2)[CH:15]=[CH:14][C:4]=1[O:5][CH2:6][C:7]([OH:9])=[O:8].[F:45][C:44]([F:47])([F:46])[C:42]([OH:48])=[O:43]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 54089176HCID 54089176, compound

Product 1

HCID 131719424HCID 131719424, compound

Procedure

Cyclopropyl adduct 300a was deprotected with TFA/CH2Cl2 in the usual way to provide a pale grey solid. IR(KBr): cm-1 3200-2500(br), 1738, 1680. HR-MS: Calc'd 411.1920, Found 411.1925.

Workup

  1. customto provide a pale grey solid

Sources & evidence

ORD record
ord-bfaa435784fe4423aad646b5b5341709
Source dataset
uspto-grants-1996_06
Patent number
US05523302

Reaction notes

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