HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 259800Generated: October 30, 2026
Ammonia → Methyl 3-amino-2-chloro-2-pentenoate
https://huagongshe.com/reaction/259800
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 2-chloro-3-oxopentanoate | HCID 545096 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3-amino-2-chloro-2-pentenoate | HCID 86749529 | 87.6% |
Reaction Steps
Dry NH3 gas is passed through a solution of 376.3 g (2.064 mol) of methyl 2-chloro-3-oxovalerate in 100 ml of methanol while stirring at 65° C. for 3 h. The solvent is removed in vacuo, the residue is taken up in diisopropyl ether, the solution is filtered through sea sand, and the solvent is evaporated. Yield: 87.6% [GC]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05523404 |
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| Source dataset | uspto-grants-1996_06 |
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| ORD ID | ord-4012ff87265f45b6a36a65cd7d2a1643 |
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| Source note | uspto-grants-1996_06 |
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