HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → 5-chloro-6-methyl-1H-pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Methyl 3-amino-2-chloro-2-butenoate | HCID 76224675 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-chloro-6-methyl-1H-pyrimidin-4-one | HCID 178433212 | — |
Reaction Steps
25.9 g (0.17 mol) of methyl 3-amino-2-chloro-2-butenoate are reacted with 11.7 g (0.26 mol) of formamide and 51 ml of sodium methylate solution in 20 ml of methanol and worked up in analogy to Example 9 (reaction time 20 h). Yield: 16.6 g (67.5%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05523404 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-58ad2a4fdb2f4d9bb1f83c2c5786fa1f |
| Source note | uspto-grants-1996_06 |