Sodium Hydroxide → N,N-Dibenzyl-L-phenylalanine

HRID 259827Notes

Reaction equation

HRID 259827 reaction equation
Cl.[CH2:2]([N:9]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[OH-].[Na+]>C(Cl)Cl>[CH2:21]([N:9]([CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69745698HCID 69745698, compound

Product 1

HCID 10980880N,N-Dibenzyl-L-phenylalanine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N,N-Dibenzyl-L-phenylalanine hydrochloride (50 g) was dissolved in methylene chloride (500 ml), and an aqueous solution of sodium hydroxide (sodium hydroxide 6 g, water 500 ml) was added thereto. After stirring the mixture for 30 minutes, it was partitioned, and the organic layer was dried over magnesium sulfate and concentrated under reduced pressure to give N,N-dibenzyl-L-phenylalanine as an oily substance.

Workup

  1. customit was partitioned
  2. dry with materialthe organic layer was dried over magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-5bd915c8abba4ef192747210afc6e22e
Source dataset
uspto-grants-1996_06
Patent number
US05523410

Reaction notes

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