反应详情

To methyl 2(S)-hydroxy-3-phenylpropionate (5.0 g) and pyridine (8.78 g) in methylene chloride (50 ml) was dropwise added phenyl chlorocarbonate (4.78 g) under cooling at 0°-10° C. over 30 minutes. After the dropwise addition, the mixture was stirred at said temperature for 60 minutes, washed with 10% hydrochloric acid and water, dried over magnesium sulfate, and concentrated to dryness under reduced pressure. As a result, 9.51 g of methyl 2(S)-phenoxycarbonyloxy-3-phenylpropionate was obtained as a pale yellow, oily substance.

1. temperatureunder cooling at 0°-10° C. over 30 minutes
2. additionAfter the dropwise addition
3. customfor 60 minutes
4. washwashed with 10% hydrochloric acid and water
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated to dryness under reduced pressure