Magnesium → HCID 178460931, compound

Participants

Reaction Steps

4.7 g (20 mmol) of trans-1-(1-propenyl)-4-bromomethyl-1-silacyclohexane was dripped into a mixture of 0.5 g (21 mmol) of magnesium and 50 ml of THF to obtain a Grignard's reagent. This solution was then dripped into a 50 ml THF solution of 5.7 g (20 mmol) of 4'-bromomethyl-3,4-difluorobiphenyl and a catalytic amount of cuprous chloride to obtain 4-[2-(trans-4-(1-propenyl)-4-silacyclohexyl) ethyl]-3',4'-difluorobiphenyl. The silacyclohexane rings of this product were a mixture of trans isomers and cis isomers. After a conventional after treatment, they were separated by means of chromatography to obtain 6.1 g of the trans isomers (yield 86%).

Provenance & Evidence