HCID 57020529, compound → HCID 57172727, compound

HRID 259906Notes

Reaction equation

HRID 259906 reaction equation
C([N:8]([C@H:16]([C@@H:24]([OH:38])[CH2:25][C@@H:26]([NH:34][C:35](=[O:37])[CH3:36])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)CC1C=CC=CC=1)C1C=CC=CC=1>CO.[C].[Pd]>[NH2:8][C@H:16]([C@@H:24]([OH:38])[CH2:25][C@@H:26]([NH:34][C:35](=[O:37])[CH3:36])[CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 1

HCID 57020529HCID 57020529, compound

Product 1

HCID 57172727HCID 57172727, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Conditions

Temperature
30 °C

Procedure

To a solution of 100 g of (2S,3S,5S)-2-(N,N-dibenzylamino)-5-acetylamino-1,6-diphenyl-3-hexanol in 500 ml of methanol, was added 5 g of 5%-palladium-carbon (product of N. E. Chemcat), and the reaction mixture was stirred at 30° C. for 30 hours under a hydrogen atmosphere of 10 atm.

Sources & evidence

ORD record
ord-c18c6e6554eb4a369add11e81006ca59
Source dataset
uspto-grants-1996_06
Patent number
US05523458

Reaction notes

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