Methanol → 3,4,5,6-Tetrafluorophthalic acid-monomethyl ester

HRID 259954Notes

Reaction equation

HRID 259954 reaction equation
[F:1][C:2]1[C:3]([F:15])=[C:4]([F:14])[C:5]([F:13])=[C:6]2[C:11](=[O:12])[O:10][C:8](=[O:9])[C:7]=12.[CH3:16][OH:17]>>[CH3:16][O:17][C:11](=[O:12])[C:6]1[C:7](=[C:2]([F:1])[C:3]([F:15])=[C:4]([F:14])[C:5]=1[F:13])[C:8]([OH:10])=[O:9]

Participants

3

Reactant 2

HCID 887Methanol2×HCID 69545Tetrafluorophthalic anhydride

Product 1

HCID 108579443,4,5,6-Tetrafluorophthalic acid-monomethyl esterYield 98%

Procedure

Into a 100 ml glass reactor equipped with a reflux condenser and a stirrer, 20 g (0.091 mol) of the tetrafluorophthalic anhydride prepared in Example 3 and 40 ml of methanol were charged, and the mixture was stirred for 2 hours under reflux. After completion of the reaction, methanol was distilled off to obtain 22.5 g of 3,4,5,6-tetrafluorophthalic acid-monomethyl ester. The yield was 98.0%.

Workup

  1. customInto a 100 ml glass reactor equipped with a reflux condenser and a stirrer
  2. temperatureunder reflux
  3. distillationwas distilled off

Sources & evidence

ORD record
ord-b7c0172d3be94423933cdac74876da78
Source dataset
uspto-grants-1996_06
Patent number
US05523476

Reaction notes

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