Hydrochloric Acid → 4-Methoxy-3,5,6-trifluorophthalic acid-1-methyl ester

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Reaction Steps

Into a 100 ml glass reactor equipped with a reflux condenser, a stirrer and a dropping funnel, 20 ml of a methanol solution of 10 g (0.0397 mol) of the 3,4,5,6-tetrafluorophtalic acid-monomethyl ester prepared in Example 14 was charged. Then, 8.21 g (0.060 mol) of potassium carbonate was added thereto. The mixture was stirred for 3 hours under reflux. After completion of the reaction, the reaction mixture was neutralized with a 10% hydrochloric acid aqueous solution and extracted with ethyl acetate. Then, the solvent was distilled off to obtain 8.7 g of 4-methoxy-3,5,6-trifluorophthalic acid-1-methyl ester. (=5-methoxy-3,4,6-trifluorophthalic acid-2-methyl ester.) The yield was 83.1%.

Provenance & Evidence