Sodium Hydroxide → HCID 10242690, compound

HRID 25999Notes

Reaction equation

HRID 25999 reaction equation
Cl.[CH2:2]1[O:10][C:9]2[CH:8]=[CH:7][C:6]([CH:11]([OH:17])[CH2:12][NH:13][CH:14]([CH3:16])[CH3:15])=[CH:5][C:4]=2[O:3]1.[OH-].[Na+]>O>[CH2:2]1[O:10][C:9]2[CH:8]=[CH:7][C:6]([CH:11]([OH:17])[CH2:12][NH:13][CH:14]([CH3:15])[CH3:16])=[CH:5][C:4]=2[O:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 123482941-(3,4-Methylenedioxyphenyl)-2-isopropylaminoethanol hydrochloride

Product 1

HCID 10242690HCID 10242690, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 g. of 1-(3,4-methylenedioxyphenyl)-2-isopropylaminoethanol hydrochloride are dissolved in 20 mol. of water, and the resulting aqueous solution is made basic with 1N caustic soda. The liberated oil is extracted with ether. The ether layer is separated and dried and the ether is removed by distillation. Upon recrystallization of the crystalline residue from petroleum ether, 1-(3,4-methylenedioxyphenyl)-2-isopropylaminoethanol is obtained as white needle crystals having a melting point of 117°-118° C.

Workup

  1. extractionThe liberated oil is extracted with ether
  2. customThe ether layer is separated
  3. customdried
  4. customthe ether is removed by distillation
  5. customUpon recrystallization of the crystalline residue from petroleum ether

Sources & evidence

ORD record
ord-a7be1f2431724a97bf5efa5c8c526b27
Source dataset
uspto-grants-1979_04
Patent number
US04147799

Reaction notes

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