5-Chloro-1-(2-deoxypentofuranosyl)-4-hydroxypyrimidin-2(1H)-one → HCID 131719429, compound

HRID 260022Notes

Reaction equation

[CH2:1]1[C@H:5]([N:6]2[C:12](=[O:13])[NH:11][C:9](=[O:10])[C:8]([Cl:14])=[CH:7]2)[O:4][C@H:3]([CH2:15][OH:16])[C@H:2]1[OH:17].[C:18]1([C:26]([O-:28])=[O:27])[NH:25][C:23](=[O:24])[NH:22][C:20](=[O:21])[N:19]=1.[K+:29]>>[CH2:1]1[C@H:5]([N:6]2[C:12](=[O:13])[NH:11][C:9](=[O:10])[C:8]([Cl:14])=[CH:7]2)[O:4][C@H:3]([CH2:15][OH:16])[C@H:2]1[OH:17].[C:18]1([C:26]([O-:28])=[O:27])[NH:25][C:23](=[O:24])[NH:22][C:20](=[O:21])[N:19]=1.[K+:29]

Participants

Reactant 2

HCID 655105-Chloro-1-(2-deoxypentofuranosyl)-4-hydroxypyrimidin-2(1H)-one

HCID 2723920Potassium oxonate

Product 1

HCID 131719429HCID 131719429, compound

Procedure

FT, ClDU and potassium oxonate were suspended at concentrations of 2.0 mg/ml, 0.73 mg/ml and 1.95 mg/ml, respectively, in a 1% solution of hydroxypropylmethylcellulose. The suspension was stirred by a stirrer at room temperature for about 20 minutes and subjected to ultrasonic treatment with ice-cooling for 5 minutes, giving a FT-ClDU-potassium oxonate mixed suspension (test suspension (4)). Test suspensions (5) and (6) were prepared by adding a 1% solution of hydroxypropylmethylcellulose to test suspension (4) to give FT concentrations of 1.0 and 0.5 mg/ml, respectively.

Workup

temperaturecooling for 5 minutes

Sources & evidence

ORD record: ord-0c705bfa8b6848bca780768d8693c068
Source dataset: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05525603

Reaction notes

Loading…