Octahydropentalene-1-carboxylic acid → HCID 54132780, compound

HRID 260038Notes

Reaction equation

HRID 260038 reaction equation
[NH2:1][C:2]1[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[S:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=1[NH2:8].[CH:17]12[CH2:24][CH2:23][CH2:22][CH:21]1[CH2:20][CH2:19][CH:18]2[C:25](O)=O>>[C@@H:17]12[CH2:24][CH2:23][CH2:22][C@@H:21]1[CH2:20][CH2:19][C@H:18]2[C:25]1[NH:1][C:2]2[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[S:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 345452Octahydropentalene-1-carboxylic acidHCID 21784961HCID 21784961, compound

Product 1

HCID 54132780HCID 54132780, compoundYield 57%

Procedure

The substantially same operations as in Example 1 were repeated except for using 2.00 g (8.26 mmol) of 5,6-diamino-1,3-dipropyl-2-thiouracil [J. Med. Chem., 32, 1873 (1989)] and 1.42 ml (9.92 mmol) of bicyclo[3.3.01octan-2-carboxylic acid to afford 1.70 g (overall yield: 57%) of the captioned Compound 24 as a white crystal.

Sources & evidence

ORD record
ord-101d053d89fa4579aa2370f18d1aea03
Source dataset
uspto-grants-1996_06
Patent number
US05525607

Reaction notes

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