Boron tribromide → HCID 15285937, compound

Participants

Reaction Steps

To a solution of 0.70 g of 5-[4-(4,4,4-trifluorobutoxy)phenyl]-3-methoxyethyl-1,3,4-oxadiazol-2(3H)-one in 10 ml of dichloromethane are added dropwise 1.2 g of boron tribromide. The mixture is left to react overnight and is then treated with aqueous sodium bicarbonate solution and extracted with dichloromethane. The organic phase is washed with water, dried over sodium sulphate and concentrated. The crude product obtained is purified on a column of silica with a 1/1 mixture of ethyl acetate and heptane. 200 mg of product are obtained.

Provenance & Evidence