HCID 15230315, compound → HCID 15230316, compound

HRID 260083Notes

Reaction equation

HRID 260083 reaction equation
[C:1]1([CH:7]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:8]([N:10]2[CH:19]([C:20]([O:22][CH3:23])=[O:21])[CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:34][CH3:35])[C:16]=3[O:24][C:25]3[CH:30]=[CH:29][C:28]([N+:31]([O-])=O)=[CH:27][CH:26]=3)[CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.C1COCC1.[Pd]>[NH2:31][C:28]1[CH:29]=[CH:30][C:25]([O:24][C:16]2[C:15]([O:34][CH3:35])=[CH:14][CH:13]=[C:12]3[C:17]=2[CH2:18][CH:19]([C:20]([O:22][CH3:23])=[O:21])[N:10]([C:8](=[O:9])[CH:7]([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:11]3)=[CH:26][CH:27]=1

Participants

4

Reactant 1

HCID 15230315HCID 15230315, compound

Product 1

HCID 15230316HCID 15230316, compoundYield 0.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

A solution of 0.80 g (1.45 mole) of the nitrobenzene derivative of Example 43 in 50% methanol-THF is reduced with 5% palladium-on-carbon catalyst. The filtered solution is concentrated at reduced pressure to give 0.75 g of pure product as a solid foam; mass spectrum (EI) 522 (M+).

Workup

  1. concentrationThe filtered solution is concentrated at reduced pressure

Sources & evidence

ORD record
ord-ea833b88bb3445098057e55f87870413
Source dataset
uspto-grants-1996_06
Patent number
US05525614

Reaction notes

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