Methylglyoxal → 4-Amino-7-methylpteridin-2(3H)-one

HRID 260149Notes

Reaction equation

HRID 260149 reaction equation
Cl.[NH2:2][C:3]1[C:8]([NH2:9])=[C:7]([NH2:10])[NH:6][C:5](=[O:11])[N:4]=1.[CH3:12][C:13]([CH:15]=O)=O>O>[NH2:2][C:3]1[C:8]2[C:7](=[N:10][C:13]([CH3:15])=[CH:12][N:9]=2)[NH:6][C:5](=[O:11])[N:4]=1

Participants

4

Reactant 2

HCID 880MethylglyoxalHCID 19967541HCID 19967541, compound

Product 1

HCID 1784300614-Amino-7-methylpteridin-2(3H)-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In 50 mL of H2O is dissolved 1.77 g (0.01 mole) of 4,5,6-triamino-pyrimidine-2-one hydrochloride (19). The pH of the solution is adjusted to 5 and then, 4 mL of 40% aqueous methylglyoxal (FLUKA AG, Switzerland) is added and the solution is heated under reflux for 30 minutes. The resulting precipitate is collected and purified by recrystallization from a large amount of H2O to give 20.

Workup

  1. temperaturethe solution is heated
  2. temperatureunder reflux for 30 minutes
  3. customThe resulting precipitate is collected
  4. custompurified by recrystallization from a large amount of H2O

Sources & evidence

ORD record
ord-5bb7f9975374467e8247e2817c9a6339
Source dataset
uspto-grants-1996_06
Patent number
US05525711

Reaction notes

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