Benzoyl chloride → HCID 19967563, compound

HRID 260150Notes

Reaction equation

HRID 260150 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[N:7][C:8]([CH3:12])=[CH:9][N:10]=2)[NH:5][C:4](=[O:13])[N:3]=1.[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>N1C=CC=CC=1>[C:14]([NH:1][C:2]1[C:11]2[C:6](=[N:7][C:8]([CH3:12])=[CH:9][N:10]=2)[NH:5][C:4](=[O:13])[N:3]=1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 1784300614-Amino-7-methylpteridin-2(3H)-one

Product 1

HCID 19967563HCID 19967563, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
80 °C

Procedure

In 20 mL of pyridine is dissolved 1.63 g (0.01 mole) of 4-amino-7-methyl-pteridine-2-one (20). Then 3.12 g (0.02 mole) of benzoyl chloride is added dropwise while stirring the mixture. The mixture is heated to 80° C. for 30 minutes and then poured on ice. The resulting precipitate is collected, washed with ethanol and ether and then recrystallized from DMF to give 21.

Workup

  1. additionpoured on ice
  2. customThe resulting precipitate is collected
  3. washwashed with ethanol and ether
  4. customrecrystallized from DMF

Sources & evidence

ORD record
ord-f3b3ecb99acb420b98a6fba6535870b3
Source dataset
uspto-grants-1996_06
Patent number
US05525711

Reaction notes

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