HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylbenzene → 4-(4-Tert-butylphenyl)-4-oxobutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylbenzene | HCID 7366 | — |
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Product | 4-(4-Tert-butylphenyl)-4-oxobutanoic acid | HCID 2064037 | 68% |
Reaction Steps
tert-Butylbenzene 10e (99%, 4.3 eq) was reacted with succinic anhydride (99%, 1 eq) and AlCl3 (95%, 2 eq) for 120 h according to the general procedure. Extractive purification of the crude product afforded white crystals of 11e in 68% yield. 1H-NMR: 7.93 (d, 2H Ar--H); 7.48 (d, 2H, Ar--H); 3.30 (t, 2H, CH2CH2COOH); 2.81 (t, 2H, CH2CH2COOH); 1.34 (s, 9H, CH3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05525736 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-4de3fd80e15846a7b8b2fb196f472ce0 |
| Source note | uspto-grants-1996_06 |