HuagongsheHuagongshe Chemistry Print Report · For research reference only
Succinic anhydride → 4-Oxo-4-(2,4,6-trimethylphenyl)butanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | Mesitylene | HCID 7947 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Product | 4-Oxo-4-(2,4,6-trimethylphenyl)butanoic acid | HCID 346180 | 54% |
Reaction Steps
Mesitylene 10i (99%, 4.8 eq) was reacted with succinic anhydride (99%, 1 eq) and AlCl3 (95%, 2 eq) for 72 h according to the general procedure. Extractive purification of the crude product afforded white crystals of 11i in 54% yield. 1H-NMR (DMSO-d6): 6.63 (s, 2H, Ar--H); 2.84 (t, 2H, CH2CH2COOH); 2.22 (s, 3H, p-CH3); 2.18 (t, 2H, CH2CH2COOH); 2.13 (s, 6H, o-CH3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05525736 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-8afe87d178e6471fbe0eaf4d50f27741 |
| Source note | uspto-grants-1996_06 |