Hydrochloric Acid → HCID 22842379, compound

Participants

Reaction Steps

Morphine sulfate (1.67 g, 5×10-3 mol) was dissolved with potassium carbonate (2.07 g, 1.5×10-2 mol) in 80 ml ethanol. The solution was heated to reflux while stirring and a solution containing bromoacetic acid (0.7 g, 5×10-3 mol) added in 2 ml ethanol. This was refluxed for 2 hr, then the flask was cooled in an ice-water bath. The pH was adjusted to 3 with 12N hydrochloric acid and precipitates were filtered. Solvents were evaporated under vacuum and 10 ml ethanol was added to the residue. Precipitates were filtered and solvents evaporated under vacuum. The residue was recrystallized from water/acetone (10:90). Approximately 300 mg of the desired product was recovered.

Provenance & Evidence