Monobenzone → HCID 131719435, compound

Participants

Reaction Steps

16.4 g (0.05 mol) of N-hexadecanoyl-(l)-alanine and 8.1 g (0.05 mol) of 1,1-carbonyldiimidazole are dissolved in 100 ml of dimethylformamide, the solution is stirred at 5° for 1 hour, 10 g (0.05 mol) of 4-benzyloxyphenol in 50 ml of dimethylformamide are run in, the mixture is stirred for 18 hours and evaporated and the residue is then taken up with chloroform. After washes with water and dilute sodium hydroxide solution and drying, the title derivative is obtained in the pure state, m.p.=77°/9°, and only shows a single spot of Rf(i)=0.76 in TLC.

Provenance & Evidence