HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → Boc-Gly-Gly-Ala-Pro-OBzl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Reactant | Boc-Gly-Ala-Pro-OBzl | HCID 14656486 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | Boc-Gly-Gly-Ala-Pro-OBzl | HCID 131719402 | 85.9% |
Reaction Steps
Compound II (65.03 g, 0.15 mole) was deblocked with HCl/dioxane and coupled to Boc-Gly-OH (26.3 g, 0.15 mole) using EDCI with HOBt in the same manner as that described for II to give 63.2 g (yield 85.9%) of III R1f, 0.3; R2f, 0.46.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05527610 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-4b85a178f50b471595146f5f08f0c168 |
| Source note | uspto-grants-1996_06 |